Within the field of Drug Discovery, designing new scaffolds and easy accessible chemistry is very important. Through MCR Chemistry we try to develop druglike molecules in the following projects;
Scaffolds:
- Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
- The Gewald multicomponent reaction
- Polycyclic Compounds by Ugi−Pictet−Spengler Sequence
- Efficient Multicomponent Reaction Synthesis of the Schistosomiasis Drug Praziquantel
- Cyanoacetamide MCR (III): Three-Component Gewald Reactions Revisited
- One-pot Synthesis Of Highly Functionalized Seleno Aminoacid Derivatives
- (-)Bacillamide C: The Convergent Approach
Medicinal Chemistry:
- Parallel Synthesis Of Arrays Of 1,4,5-Trisubstituted 1-(4-Piperidyl)-Imidazoles By IMCR: A Novel Class Of Aspartyl Protease Inhibitors
- Novel Anti-Tuberculosis Agents from MCR Libraries
- One-Pot Synthesis of 2-Amino-indole-3-carboxamides
- Praziquantel and Schistosomiasis
Protein Protein Interactions:
- Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?
- Screening Multicomponent Reactions for X-Linked Inhibitor of Apoptosis-Baculoviral Inhibitor of Apoptosis Protein Repeats Domain Binder
- Identification of Hsp70 modulators through modeling of the substrate binding domain
- Towards Erythropoietin mimicking Small Molecules
p53 mdm2 mdm4:
- Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists
- The Structure-Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious
- Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug Discovery (open access)